Strickler Goedert Hypothesis

“Overall, the association of prostate cancer with sexual history and, particularly, sexually transmitted diseases has been suggested by case-control investigations, but these relations are not firmly established. Although it is not possible to entirely rule out a role for human papillomavirus or other known sexually transmitted infections in a subset of prostate cancers, the failure of studies using sensitive polymerase chain reaction assays to consistently detect viruses in prostate cancer cells, and the marginal strength of these associations when detected, are in marked contrast to the strong, consistent association of human papillomavirus with cervical cancer (ORs = 30-100 or more). Instead, the situation has similarities to that observed for cervical cancer before the association with human papillomavirus was understood: a moderate association was found with sexual behavior and occasional weak associations were found with herpes simplex virus or other sexually transmitted infections, each acting as surrogates for human papillomavirus. By analogy, the findings reviewed above could reflect a yet unrecognized sexually transmitted infection etiologically related to a subset of prostate cancer.” Strickler et Goedert, 2001

Because many additional bacterial sequences, and now a new viral sequence, can be found in prostate tissue in the absence of an ability to culture any of these organisms using traditional means, it is still possible that in analogy to H. pylori gastritis, researchers have missed a previously unidentified pathogen associated with most inflammatory lesions in the prostate.Demarzo et al, 2007

This meta-analysis provides evidence of a higher rate of prostate cancer in men with a history of an exposure to gonorrhea, HPV, or any STD.” Taylor et al, 2005