Could protein PSP94 be the key to understanding the etiology of prostate cancer?

Several lines of evidence support a role for infectious agents in the development of prostate cancer. […] Circumcision before first sexual intercourse is associated with a reduction in the relative risk of [prostate cancer] in this study population. These findings are consistent with research supporting the infectious/inflammation pathway in prostate carcinogenesis.” Wright et al 2012 (see also the Strickler Goedert Hypothesis and criticism of this study [1] [2])

Seminal plasma displayed prominent fungicidal effects at a 1000-fold dilution[…] The fungicidal activity of seminal plasma was mediated by [PSP94]. Edstrom et al 2012

The most strongly associated [prostate cancer] SNP rs10993994 is 2 bp upstream of the transcription start site of [PSP94's gene]. Its location and the strength of the association raises the possibility that this SNP may be causally related to [prostate cancer] risk.” Eeles et al 2008

Additional copies of the [rs10993994] risk allele for prostate cancer, T, correlated with lower levels of [PSP94].” Xu et al 2010

"PSP94, what is it good for?" 
explores the hypothesis that a sexually transmissible infectious agent targeted by PSP94 is causing prostate cancer and BPH. It thoroughly reviews PSP94 studies from the scientific literature, and reaches a robust conclusion. It is published under the Creative Commons Attribution-NonCommercial-NoDerivatives License (v4.0 International), allowing free distribution and reproduction. When researchers manage to genetically identify the infectious agent responsible for prostate cancer, preventative strategies will be developed which will save millions of lives. The following studies were based in part on "PSP94, what is it good for?":

Following the theory proposed by Laurence, the present study provides initial epidemiological support for the hypothesis that the PSP94 protein may inhibit the adverse effects of a sexually transmitted pathogen on prostatic tissue, since men who carry the T allele of rs10993994 have been shown to have lower PSP94 expression in prostate tissue and lower PSP94 concentrations in urine, and are also at increased risk for [prostate cancer]. […] PSP94 does exhibit strong fungicidal activity, and Laurence proposes the novel idea that a candidate STI organism may be fungal in origin. Stott-Miller et al 2013

While many studies have examined viral and intracellular bacterial infections, very few studies—only one, to our knowledge—have investigated fungal infections in relation to prostate cancer. This paucity of mycotic research is likely due to the low documented occurrence of symptomatic fungal prostate infections. Sutcliffe et al 2014

Evidence reviewed here lends credence to the Catterall–King hypothesis and implicates a common fungal etiology in prostate cancer, benign prostatic hyperplasia, multiple sclerosis, psoriasis, inflammatory bowel disease, and spondyloarthritis. Laurence et al 2018

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